Upon entering the dream player should drink overdose and OSRS gold take the all hitpoints remaining down to 1 by using the wither locator orb as well as rock cake. This causes bosses to hit only one which is shielded for duration of time due to absorption potions. For the equipment you should bring highest damage output set that you have (Dharok works very well).
Additionally, there are other powerful gear items that can aid you in your fight : Berserker Ring, Seers Ring, Archers Ring, Abyssal Whip, Salve Amulet, Warrior Rings, Void Knight Set, Ardougne Cloak, Anti Fire Shield, Proselyte Armour, God Book, Granite Maul, Amulet of Fury and many more. Be sure to carry potions such as super magic super-ranging, super melee.
If you've stumbled across the this nightmare zone to improve your experience on afk training this section is for you. To start off just go to one of the corners in the nightmare so that bosses are unable to touch you (remember you'll need melee bosses for it to work).
If you're looking to block with your normal overload / absorption combo keep in mind that the effects will last for about 5 minutes. There is a way to extend this time period to 20 minutes by using powerful potions for combat instead of overloads. For those who want to stay AFK for longer, it's possible to battle bosses on normal mode with Guthan set for 20 minutes however it's not recommended since it wont give any gaming experience.
The most important thing to remember when training in nightmare environments is gathering points for overload and absorption potions. It's best to purchase the entire inventory each whenever you enter a dream. There is a second method of spending points when you're close to achieving the cap. This should only be done when you know that you will have enough points to buy old school rs gold purchase another batch of potion.