Passengers and commuters are facing major disruption as nearly all trains in Wales are cancelled on Wednesday.
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More than 40,000 UK railway workers, who are part of the RMT union, are set take part in national strikes over pay.
Transport for Wales (TfW) urged people "only to travel by rail if necessary" during the industrial action.
TfW said the strikes would cause "severe disruption" across the whole of the UK.
TfW is not in dispute with the National Union of Rail, Maritime, and Transport Workers (RMT), but as Network Rail maintains tracks services in Wales will be hit.
This means only a handful of trains will be running on Wednesday.
The action comes a month after passengers were urged to avoid travelling by rail as almost all trains ground to a halt during the biggest strike in 30 years.