The increased effort required to breathe can lead to a higher metabolic rate and increased calorie expenditure. As a result, individuals with COPD may experience unintentional weight loss and muscle wasting. Gastrointestinal disorders: Conditions such as Crohn's disease, ulcerative colitis, or gastroparesis can interfere with digestion, nutrient absorption, and appetite. Chronic inflammation, intestinal damage, or delayed gastric emptying can contribute to weight loss. Depression and anxiety: Mental health disorders can impact appetite, leading to weight loss or gain. In the case of depression or anxiety, changes in appetite and eating patterns are common. Some individuals may experience a loss of interest in food or have difficulty eating, resulting in unintentional weight loss. These are just a few examples of weight loss diseases. If you or someone you know is experiencing unexplained or significant weight loss, it is crucial to consult a healthcare professional for a proper diagnosis and appropriate treatment.