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Over 99% pure Calcium Alpha-Ketoglutarate powder Independently lab tested 100% Natural, Non-GMO Gluten-Free, vegan and allergy friendly Free 0.50ml scoop with every order Free UK delivery on all orders   Ca-AKG has been found to possess numerous potential health-related benefits including: Promoting cellular energy* Supporting the fight of free radicals* Detoxifing ammonia levels in cells* Helping maintain DNA structure* What Is Calcium Alpha-Ketoglutarate Calcium Alpha-ketoglutarate (Ca-AKG) is a compound created naturally in the body but diminishes as we age. A 2008 review article on the subject noted AKG blood levels can drop by a factor of ten between the ages of 40 and 80, suggesting that Ca-AKG supplementation in middle-age could have longevity promoting effects into old age. Ca-AKG is an intermediate compound that produces energy in the body in a series of reactions and is the precursor to the amino acids glutamine and glutamate. A multi year study at the Buck Institute for Research on aging has indicated that in animal models, Ca-AKG can promote longer, healthier lives associated with a decrease in levels of inflammatory cytokines. Furthermore, the reduction in frailty was observed to be more dramatic than the increase in lifespan, suggesting that Ca-AKG compresses the period of later-life suffering of disease. The same study found that Ca-AKG was found to modulate the pathways that are associated with healthy aging, including DNA de-methylation, and potentially decreases biological age as defined by the science of biological clocks. The study focused on 31 frailty markers and tested for a multitude of biomarkers related to aging and inflammation. The researchers found that mice in the test group experienced a 12% increase in lifespan, and perhaps even more significantly, a 46% reduction in frailty, and 41% increase in healthspan. How Does It Work? Calcium Alpha-Ketoglutarate works in numerous pathways within the body and follows the same catabolic pathways as amino acid, working by improving the digestion of protein in the body. AKG restores cellular energy and facilitates cell renewal which reduces the progression of age-related illnesses and frailty. It has protective properties from a number of the natural progression of ageing, many of which are caused by age-related inflammation and loss of bone mineral density. Dosage and Guidance Take with or without food. Can be mixed in a meal or drink.   Suggested Daily Dosage: 1 grams per day. Upper Dosage (Depending upon the age and other factors): 2 grams per day. Referencing and Further Readings: For the individuals who are interested in more details and knowledge about Calcium Alpha ketoglutarate (Ca-AKG) and Alpha ketoglutarate (AKG), here is a list of references to help you with your study. Moreover, you can watch this video by Lecturio Medical where the professional is discusses the Calcium Alpha ketoglutarate (Ca-AKG) family and Glutamine syntheses.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703346/ Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1. https://www.fightaging.org/archives/2020/07/calcium-alpha-ketoglutarate-supplementation-reduces-epigenetic-age-in-humans/ Hajishengallis, G., 2010. Too old to fight? Aging and its toll on innate immunity. Molecular oral microbiology, 25(1), pp.25-37. https://www.webmd.com/vitamins/ai/ingredientmono-144/alpha-ketoglutarate-akg Xiao, D., Zeng, L., Yao, K., Kong, X., Wu, G. and Yin, Y., 2016. The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications. Amino acids, 48(9), pp.2067-2080. https://www.prnewswire.com/news-releases/study-reveals-longevity-benefits-of-calcium-alpha-ketoglutarate-in-scientific-journal-cell-metabolism-301122432.html Shahmirzadi, A.A., Edgar, D., Liao, C.Y., Hsu, Y.M., Lucanic, M., Shahmirzadi, A.A., Wiley, C.D., Gan, G., Kim, D.E., Kasler, H.G. and Kuehnemann, C., 2020. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metabolism, 32(3), pp.447-456. https://selfhacked.com/blog/health-benefits-aakg/ Kaczka, P., Batra, A., Kubicka, K., Maciejczyk, M., Jastrząb, R., Kopera, E., Bira, J. and Zając, T., 2020. Effects of Co-Ingestion of AAKG and HMB on Jumping Performance in Young Track and Field Athletes. https://www.hindawi.com/journals/bmri/2018/3408467/ Liu, S., He, L. and Yao, K., 2018. The antioxidative function of alpha-ketoglutarate and its applications. BioMed research international, 2018. http://www.biomolther.org/journal/view.html?volume=24&number=1&spage=1&year=2016 Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1. https://www.verywellhealth.com/the-benefits-of-alpha-ketoglutaric-acid-89402 Prandini, A., Morlacchini, M., Sigolo, S., Fiorentini, L. and Gallo, A., 2012. Anticatabolic activity of alpha-ketoglutaric acid in growing rats. Italian Journal of Animal Science, 11(3), p.e52. https://europepmc.org/article/med/1808834 Dulaney Jr, M.D., Brumley, M., Willis, J.T. and Hume, A.S., 1991. Protection against cyanide toxicity by oral alpha-ketoglutaric acid. Veterinary and human toxicology, 33(6), pp.571-575. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703346/ Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1.   Disclaimers: It is advised to use this product at your own discretion. Ca-AKG general consumption started in the 2000’s and long-term effects on humans are yet to be determined.  Our products are supplements and should not be considered as an alternative for a varied diet. Consult with your doctor before incorporating it into your daily routine. Research on Ca-AKG is still ongoing and as more is discovered, the content on this website may get updated or changed altogether.

Welcome to LongevityBox, Buy NMN supplement powder online in the UK. We offer the best NMN supplement powder online at the lowest prices.

Over 99% Pure NMN Sublingual Powder Supplement Independently lab tested 100% Natural, Non-GMO Gluten-Free, vegan and allergy friendly Free 0.5g scoop with every order Free UK delivery on all orders Nicotinamide Mononucleotide, also known as NMN (beta-Nicotinamide mononucleotide or β-NMN) is an entirely natural compound found in our bodies that has been scientifically synthesized and found to be a powerful antiaging supplement. Scientifically speaking, it is a nucleotide that has been derived from ribose and nicotinamide. Its chemical formula is C11H15N2O8P and it is a vitamin B3 Metabolite. Besides the human body, it is also found in food items such as cabbage or broccoli in traces.   It is a ribonucleotide (nucleic acid RNA’s basic structural unit) on a molecular level, with its structural molecular composition comprising: Nicotinamide group Ribose Phosphate group In 2013, a breakthrough study conducted on mice by scientists at Harvard University revealed it to be a powerful anti-aging compound and emphasized its importance for human consumption. In 2015, it was synthesized by scientists but the process for its manufacturing was very costly. It wasn’t until around 2018 that it was refined sufficiently and production costs were reduced enough for it to be ready for mass production.    How Does NMN Work?   NMN is the direct precursor of Nicotinamide Adenine Dinucleotide or NAD+ and plays a vital role to increase the amount of NAD+ in human cells. NAD+ is an essential coenzyme (coenzymes are catalysts needed by enzymes to complete their biochemical reactions) that is essential for a number of cellular functions. NAD+ happens to be the 2nd most abundant molecule in the human body with water being the first; without NAD+, it is present in all organisms and an important benefactor for life.    NAD+ is an oxidized form of NAD and was first discovered in 1906. Supplements containing NAD+ can’t help to boost the level of NAD+ in the human body because of the large size of the molecule that prevents it from crossing the cell membrane to enter cells. This is why NMN needs to be consumed in order to boost the production of NAD+ molecule that is not only good for mitochondria (the powerhouse of the cell) but also for a number of proteins throughout the body such as Sirtuins that help to repair DNA that has been damaged by aging. Additionally, it has also been shown to reverse the adverse effects of age-related diseases in lab trials conducted on animals; this includes: Fighting against metabolic disorders Regulating and improving heart functions Reducing Neurodegeneration Strengthening immune system Preventing age-related diseases such as diabetes, arthritis, cataracts, Alzheimer’s disease, etc.   Health expert Rhonda Patrick explains what NAD+ is, why it is so important for aging and why it declines with age. She discusses the NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide.   Dosage and Guidelines: Initial Precaution: NMN represents one of the final steps of NAD+ synthesis besides all the other precursors that play their part in its production, hence its importance for the production of NAD+ is undeniably more significant. In terms of dosage, it is advised to all the individuals taking it for the first time to start with a low dose and take the first dose to determine whether the product suits them or if their body reacting against it (it is highly unlikely and no such cases have been recorded). The first dose should not exceed more than 50-60 mg and taken as per the directions indicated on the packaging. The subject should monitor themselves carefully and remain responsive towards any possible adverse side-effects or reactions. It is most likely that there won’t be any reaction/s, in which, case, the subject can proceed with regular dosage from the following day.    Directions for Regular Use: The most preferred administration for NMN is ‘Sublingual Administration’ where the subject should place their daily dose under their tongue and allow it to dissolve and be absorbed. To increase the effectiveness, it is advised to divide the daily dose into smaller portions that the subject should consume throughout the day. Alternatively, the daily recommended dose can be mixed in 100ml water and drunk. The water-mixed dose may also be sprinkled onto food and consumed (this method may lower the bio-availability of NMN).   Note: The best method for the administration of NMN is still debated upon as some studies suggest that the oral consumption of NMN blocks or limits its delivery to tissues by the liver. On the other hand, several studies suggest the existence of a transporter gene in the small intestine from where it is carried away to cells.  The advantage of sublingual administration over forms of consumption is that it allows for direct absorption of NMN into the blood and bypasses the digestive tract, hence resulting in a much more efficient rate of absorption.   Recommended Daily Dosage: O.5 grams per day. Upped Dosage (Depending upon the age and other factors): 1 gram per day.   Suggestion: We suggest our valued clients take periodic breaks from NMN (one to two days off) on a weekly basis. though there is no evidence to suggest whether this practice is beneficial or not, it has been observed that periodic breaks can help the body to respond positively to such treatments.   Note: If you are on prescribed medication or have been medicating for a long term previously, then it is best to consult with your doctor before starting with NMN.  Keep the contents in the provided packaging or an airtight glass jar. Keep away from sunlight and avoid exposure to a temperature above 24 degrees Celsius. Keep in a cool dry place and don’t expose the contents to moisture. This product can be kept in a fridge or refrigerator.   References and Further Readings: For the convenience of the customers and enthusiasts, listed below are several links for references. Please keep in mind that none of the sources listed below are affiliated with (insert company name) in any way. For video resources, you can watch this video for Dr. David Sinclair (duration 1 hour and 12 minutes). This is also an excellent resource with a lot of useful information from Dr. Brad Stanfield (duration 30 minutes).  https://www.cell.com/cell-metabolism/pdf/S1550-4131(17)30670-8.pdf Cell.com. 2021. [online] Available at: <https://www.cell.com/cell-metabolism/pdf/S1550-4131(17)30670-8.pdf> [Accessed 1 February 2021]. https://en.wikipedia.org/wiki/Nicotinamide_mononucleotide En.wikipedia.org. 2021. Nicotinamide mononucleotide. [online] Available at: <https://en.wikipedia.org/wiki/Nicotinamide_mononucleotide> [Accessed 1 February 2021]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456119/ Li, J., Bonkowski, M.S., Moniot, S., Zhang, D., Hubbard, B.P., Ling, A.J., Rajman, L.A., Qin, B., Lou, Z., Gorbunova, V. and Aravind, L., 2017. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science, 355(6331), pp.1312-1317. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076149/ Gomes, A.P., Price, N.L., Ling, A.J., Moslehi, J.J., Montgomery, M.K., Rajman, L., White, J.P., Teodoro, J.S., Wrann, C.D., Hubbard, B.P. and Mercken, E.M., 2013. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), pp.1624-1638. https://www.cell.com/cell/fulltext/S0092-8674(18)30152-1 Das, A., Huang, G.X., Bonkowski, M.S., Longchamp, A., Li, C., Schultz, M.B., Kim, L.J., Osborne, B., Joshi, S., Lu, Y. and Treviño-Villarreal, J.H., 2018. Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging. Cell, 173(1), pp.74-89. https://www.abc.net.au/news/2014-11-04/scientists-reverse-ageing-process-in-mice/5865714 Abc.net.au. 2021. Scientists reverse ageing process in mice. [online] Available at: <https://www.abc.net.au/news/2014-11-04/scientists-reverse-ageing-process-in-mice/5865714> [Accessed 1 February 2021]. https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide En.wikipedia.org. 2021. Nicotinamide adenine dinucleotide. [online] Available at: <https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide> [Accessed 1 February 2021]. https://pubmed.ncbi.nlm.nih.gov/24786309/ Imai, S.I. and Guarente, L., 2014. NAD+ and sirtuins in aging and disease. Trends in cell biology, 24(8), pp.464-471. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963347/ Srivastava, S., 2016. Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders. Clinical and Translational Medicine, 5(1), pp.1-11. https://pubmed.ncbi.nlm.nih.gov/19149603/ Chini, E.N., 2009. CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions. Current pharmaceutical design, 15(1), pp.57-63. https://pubmed.ncbi.nlm.nih.gov/24825348/ North, B.J., Rosenberg, M.A., Jeganathan, K.B., Hafner, A.V., Michan, S., Dai, J., Baker, D.J., Cen, Y., Wu, L.E., Sauve, A.A. and Van Deursen, J.M., 2014. SIRT 2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, 33(13), pp.1438-1453. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686634/ Elhassan, Y.S., Philp, A.A. and Lavery, G.G., 2017. Targeting NAD+ in metabolic disease: new insights into an old molecule. Journal of the Endocrine Society, 1(7), pp.816-835. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161407/ Fang, E.F., Scheibye-Knudsen, M., Chua, K.F., Mattson, M.P., Croteau, D.L. and Bohr, V.A., 2016. Nuclear DNA damage signalling to mitochondria in ageing. Nature reviews Molecular cell biology, 17(5), pp.308-321.     Our Packaging: NMN powder is provided and supplied in re-sealable food-graded/food-safe pouches/bags that are transparent on one side. This transparent-sided pouch/bag is provided in another bag/pouch that prevents any moisture or light from entering the transparent-sided pouch. It is advised to keep the clear-sided bad/pouch in this protective bag/pouch at all times. Additionally, there is a scooping spoon provided that carries 250 mg NMN powder when leveled.    Disclaimers: It is advised to use this product at your own discretion. NMN is a fairly recently discovered product and long-term effects on humans are yet to be determined.  This is just a supplement and should not be considered as an alternative for a varied diet. Consult with your doctor before incorporating it into your daily routine. The research pertaining to NMN is still ongoing and new data is surfacing on a daily basis. this means that data on our website is subject to change.  

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