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  Active Sulforaphane powder Independently lab tested 100% natural and non-GMO Gluten-free, vegan and allergy friendly Free 0.5g scoop with every order Free UK delivery on all orders   Fresh broccoli and broccoli sprouts are two of the healthiest foods available due to their high concentrations of a category of compounds called glucosinolates. The two most beneficial compounds are glucoraphanin and sulforaphane which have become the focus of longevity scientists in recent years with over 650 studies establishing the health benefits. Sulforaphane is an active compound found in many cruciferous vegetables like broccoli, cabbage, cauliflower, and kale. It has been linked to health benefits, such as improved heart health and digestion. Sulforaphane has been found to possess numerous potential health-related benefits including: Protection of cells, tissues and DNA from free radical oxidative damage Maintaining healthy and normal cholesterol levels Supporting gut health and a healthy gut microbial balance Promotion of cell health  Assists in detoxification processes Supports healthy joint cartilage  Supports bladder and prostate health   Whilst Sulforaphane is a highly beneficial compound in small doses, the amount of it in food is miniscule, for example, you would need to eat about more than a kilogram of broccoli to get significant amounts of sulforaphane. Sulforaphane is also a fragile compound which means that typical cooking and preparation can destroy a majority of the beneficial nutrients. The challenge of accessing the beneficial compounds is further complicated due to Sulforaphane being found in its inactive form within food. This inactive form - glucoraphanin  - is activated into Sulforaphane only when it comes into contact with Myrosinase. These critical Myrosinase enzymes are only released when a plant is damaged, cut, chopped, or chewed, to release myrosinase and convert inactive Myrosinase into activated Sulforaphane. Recent studies show that adding myrosinase derived from ground raw mustard seeds to cooked crucifers increases the bioavailability of sulforaphane by up to 4 times. This activation of glucoraphanin into sulforaphane is the focus for our Active Sulforaphane powder which is a proprietary blend of Sulforaphane, Myrosinase and black pepper. Dosage and Guidance Take with or without food. Can be mixed in a meal or drink. Ingredients per gram (1000mg)  >99% Pure Broccoli seed extract 880mg ‐ Providing 8mg Sulforaphane Mustard seed extract 40mg Black pepper 80mg     Recommended Daily Dosage: 1 gram per day. Upper Dosage (Depending upon the age and other factors): 3 grams per day.

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Over 99% pure powder Independently lab tested 100% natural and non-GMO Gluten-free, vegan and allergy friendly Free 0.5g scoop with every order Free UK delivery on all orders   Ca-AKG has been found to possess numerous potential health-related benefits including: Promoting cellular energy* Supporting the fight of free radicals* Detoxifing ammonia levels in cells* Helping maintain DNA structure* What Is Calcium Alpha-Ketoglutarate Calcium Alpha-ketoglutarate (Ca-AKG) is a compound created naturally in the body but diminishes as we age. A 2008 review article on the subject noted AKG blood levels can drop by a factor of ten between the ages of 40 and 80, suggesting that Ca-AKG supplementation in middle-age could have longevity promoting effects into old age. Ca-AKG is an intermediate compound that produces energy in the body in a series of reactions and is the precursor to the amino acids glutamine and glutamate. A multi year study at the Buck Institute for Research on aging has indicated that in animal models, Ca-AKG can promote longer, healthier lives associated with a decrease in levels of inflammatory cytokines. Furthermore, the reduction in frailty was observed to be more dramatic than the increase in lifespan, suggesting that Ca-AKG compresses the period of later-life suffering of disease. The same study found that Ca-AKG was found to modulate the pathways that are associated with healthy aging, including DNA de-methylation, and potentially decreases biological age as defined by the science of biological clocks. The study focused on 31 frailty markers and tested for a multitude of biomarkers related to aging and inflammation. The researchers found that mice in the test group experienced a 12% increase in lifespan, and perhaps even more significantly, a 46% reduction in frailty, and 41% increase in healthspan. How Does It Work? Calcium Alpha-Ketoglutarate works in numerous pathways within the body and follows the same catabolic pathways as amino acid, working by improving the digestion of protein in the body. AKG restores cellular energy and facilitates cell renewal which reduces the progression of age-related illnesses and frailty. It has protective properties from a number of the natural progression of ageing, many of which are caused by age-related inflammation and loss of bone mineral density. Dosage and Guidance Take with or without food. Can be mixed in a meal or drink.   Suggested Daily Dosage: 1 grams per day. Upper Dosage (Depending upon the age and other factors): 2 grams per day. Referencing and Further Readings: For the individuals who are interested in more details and knowledge about Calcium Alpha ketoglutarate (Ca-AKG) and Alpha ketoglutarate (AKG), here is a list of references to help you with your study. Moreover, you can watch this video by Lecturio Medical where the professional is discusses the Calcium Alpha ketoglutarate (Ca-AKG) family and Glutamine syntheses.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703346/ Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1. https://www.fightaging.org/archives/2020/07/calcium-alpha-ketoglutarate-supplementation-reduces-epigenetic-age-in-humans/ Hajishengallis, G., 2010. Too old to fight? Aging and its toll on innate immunity. Molecular oral microbiology, 25(1), pp.25-37. https://www.webmd.com/vitamins/ai/ingredientmono-144/alpha-ketoglutarate-akg Xiao, D., Zeng, L., Yao, K., Kong, X., Wu, G. and Yin, Y., 2016. The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications. Amino acids, 48(9), pp.2067-2080. https://www.prnewswire.com/news-releases/study-reveals-longevity-benefits-of-calcium-alpha-ketoglutarate-in-scientific-journal-cell-metabolism-301122432.html Shahmirzadi, A.A., Edgar, D., Liao, C.Y., Hsu, Y.M., Lucanic, M., Shahmirzadi, A.A., Wiley, C.D., Gan, G., Kim, D.E., Kasler, H.G. and Kuehnemann, C., 2020. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice. Cell Metabolism, 32(3), pp.447-456. https://selfhacked.com/blog/health-benefits-aakg/ Kaczka, P., Batra, A., Kubicka, K., Maciejczyk, M., Jastrząb, R., Kopera, E., Bira, J. and Zając, T., 2020. Effects of Co-Ingestion of AAKG and HMB on Jumping Performance in Young Track and Field Athletes. https://www.hindawi.com/journals/bmri/2018/3408467/ Liu, S., He, L. and Yao, K., 2018. The antioxidative function of alpha-ketoglutarate and its applications. BioMed research international, 2018. http://www.biomolther.org/journal/view.html?volume=24&number=1&spage=1&year=2016 Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1. https://www.verywellhealth.com/the-benefits-of-alpha-ketoglutaric-acid-89402 Prandini, A., Morlacchini, M., Sigolo, S., Fiorentini, L. and Gallo, A., 2012. Anticatabolic activity of alpha-ketoglutaric acid in growing rats. Italian Journal of Animal Science, 11(3), p.e52. https://europepmc.org/article/med/1808834 Dulaney Jr, M.D., Brumley, M., Willis, J.T. and Hume, A.S., 1991. Protection against cyanide toxicity by oral alpha-ketoglutaric acid. Veterinary and human toxicology, 33(6), pp.571-575. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703346/ Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y. and Li, D., 2016. Alpha-ketoglutarate: physiological functions and applications. Biomolecules & therapeutics, 24(1), p.1.   Disclaimers: It is advised to use this product at your own discretion. Ca-AKG general consumption started in the 2000’s and long-term effects on humans are yet to be determined.  Our products are supplements and should not be considered as an alternative for a varied diet. Consult with your doctor before incorporating it into your daily routine. Research on Ca-AKG is still ongoing and as more is discovered, the content on this website may get updated or changed altogether.