Тадалафил в основном метаболизируется с участием фермента CYP 3А4. Селективный ингибитор CYP 3А4 кетоконазол при приеме в дозе 400 мг/сут увеличивает AUC тадалафила (20 мг) на 312%, повышает Cmax в плазме крови на тадалафил купить без рецепта:  22%, и кетоконазол (200 мг ежедневно) увеличивает AUC одной дозы тадалафила (10 мг) на 107% и Cmax на 15% относительно...

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