Which is Stronger Oxycodone or Hydrocodone? When it comes to taking pain-relief medication, the most preferred medications are Oxycodone and Hydrocodone. These are the prescribed drugs used to treat moderate to severe pain. These can be used to treat short-term pain caused by injury or surgery as well as long-term pain such as cancer pain etc. Both are highly effective and abusive also. Before coming to Which is Stronger Oxycodone or...