What is Blue Waffle Disease, And is It Real? Back in the year 2010, there was a huge buzz on the internet about a sexually transmitted disease called blue waffle disease. In fact, people claimed that it was a very dangerous disease that affects the female genitalia. So, people began to use the term blue waffle to hint that their genitals turned blue and swelled. https://www.gudstory.com/what-is-blue-waffle-disease-and-is-it-real/