Antibody Glycan Remodeling: A New Paradigm of Precision Medicine from "Discovery" to "Design"
Introduction: The Overlooked "Switch"
The success of monoclonal antibodies is undeniable, yet the inherent glycosylation heterogeneity remains a hidden variable for efficacy and safety. Fine-tuning the Fc glycan structure directly governs critical immune effector functions like Antibody-Dependent Cellular Cytotoxicity (ADCC) and serum half-life. Traditional production processes...
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